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Scientific Publications

Peer-reviewed papers by Mikhail Shchepinov, PhD — the author of Breaking the Chains of Aging. The research spans lipid peroxidation, ferroptosis, deuterium-reinforced PUFAs, and DNA microarray technology. Filter by topic below. Full list on Google Scholar.

Full list on PubMed Google Scholar

Showing 33 of 33 publications

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Proceedings of the National Academy of Sciences (PNAS)·2016·2 400+ citations

FerroptosisLipid Peroxidation

Resolving the role of lipoxygenases in the initiation and execution of ferroptosis

ACS Central Science·2018·790+ citations

FerroptosisLipid Peroxidation

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

Nature Chemical Biology·2018·780+ citations

Identification of essential sites of lipid peroxidation in ferroptosis

Nature Chemical Biology·2023·350+ citations

FerroptosisLipid Peroxidation

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

Cell Death & Differentiation·2020·310+ citations

FerroptosisLipid PeroxidationAging & Disease

Lipid peroxidation is essential for α-synuclein-induced cell death

Journal of Neurochemistry·2015·160+ citations

FerroptosisLipid PeroxidationAging & Disease

Characterization of a patient-derived variant of GPX4 for precision therapy

Nature Chemical Biology·2022·90+ citations

Reactive oxygen species, isotope effect, essential nutrients, and enhanced longevity

Rejuvenation Research·2007·130+ citations

D-PUFAs & Reinforced LipidsAging & Disease

Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation

Free Radical Biology and Medicine·2012·140+ citations

D-PUFAs & Reinforced LipidsLipid Peroxidation

Isotope-reinforced polyunsaturated fatty acids protect yeast cells from oxidative stress

Free Radical Biology and Medicine·2011·90+ citations

D-PUFAs & Reinforced LipidsLipid Peroxidation

Isotope-reinforced polyunsaturated fatty acids protect mitochondria from oxidative stress

Free Radical Biology and Medicine·2015·80+ citations

D-PUFAs & Reinforced LipidsLipid Peroxidation

Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease

Toxicology Letters·2012·80+ citations

D-PUFAs & Reinforced LipidsAging & Disease

Threshold protective effect of deuterated polyunsaturated fatty acids on peroxidation of lipid bilayers

FEBS Journal·2019·60+ citations

D-PUFAs & Reinforced LipidsLipid Peroxidation

Polyunsaturated Fatty Acid Deuteration against Neurodegeneration

Trends in Pharmacological Sciences·2020·50+ citations

D-PUFAs & Reinforced LipidsAging & Disease

Randomized, clinical trial of RT001: early signals of efficacy in Friedreich's ataxia

Movement Disorders·2018·90+ citations

D-PUFAs & Reinforced LipidsAging & Disease

Insights into the role of oxidative stress in the pathology of Friedreich ataxia using peroxidation resistant polyunsaturated fatty acids

Redox Biology·2013·100+ citations

D-PUFAs & Reinforced LipidsAging & Disease

Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid β-peptide levels, without discernable behavioral effects in an APP/PS1 mutant transgenic mouse model of Alzheimer's disease

Neurobiology of Aging·2018·100+ citations

D-PUFAs & Reinforced LipidsAging & DiseaseLipid Peroxidation

Molecular interactions on microarrays

Nature Genetics·1999·1 200+ citations

DNA & Microarrays

Steric factors influencing hybridisation of nucleic acids to oligonucleotide arrays

Nucleic Acids Research·1997·610+ citations

DNA & Microarrays

Recent applications of bifunctional trityl groups

Chemical Society Reviews·2003·270+ citations

DNA & MicroarraysOther

Oligonucleotide dendrimers: synthesis and use as polylabelled DNA probes

Nucleic Acids Research·1997·200+ citations

DNA & Microarrays

Oligonucleotide dendrimers: stable nano-structures

Nucleic Acids Research·1999·180+ citations

DNA & Microarrays

Arachidonic acid: reconciling the dichotomy of its oxidative cascade through specific deuteration

Free Radical Research·2024·4 citations

D-PUFAs & Reinforced LipidsLipid Peroxidation

Deuterium-reinforced polyunsaturated fatty acids protect against muscle atrophy by STZ-induced diabetic mice

Free Radical Biology and Medicine·2025·3 citations

D-PUFAs & Reinforced LipidsAging & Disease

Bis-Allylic Deuterated Docosahexaenoic Acid-Esterified Phospholipids Resist In Vivo Peroxidation in Rat Brain

Journal of the American Chemical Society·2025·— citations

D-PUFAs & Reinforced LipidsLipid Peroxidation

Oral deuterated docosahexaenoic acid prevents oxidative stress-induced retinal degeneration in a mouse model recapitulating features of dry AMD

Investigative Ophthalmology & Visual Science·2025·— citations

D-PUFAs & Reinforced LipidsAging & Disease

Orally administered deuterium-reinforced docosahexaenoic acid protects against chronic retinal oxidative stress in hepcidin KO mice

Investigative Ophthalmology & Visual Science·2025·— citations

D-PUFAs & Reinforced LipidsAging & Disease

Deuterated Polyunsaturated Fatty Acids Alleviate In Vitro Skeletal Muscle Dysfunction Induced by Oxidative Stress

bioRxiv·2025·— citations

D-PUFAs & Reinforced LipidsAging & Disease

Deuterium-reinforced polyunsaturated fatty acids protect against muscle atrophy induced by type 1 diabetes in mice

bioRxiv·2024·1 citations

D-PUFAs & Reinforced LipidsAging & Disease

Neurodegenerative Disorders And Muscle Diseases Implicating Pufas

US Patent App. 19/259,412·2025·— citations

PatentsD-PUFAs & Reinforced LipidsAging & Disease

Inhibition Of Cellular Dysfunction And Cell Death With Deuterated Polyunsaturated Fatty Acids

US Patent App. 19/187,478·2025·— citations

PatentsD-PUFAs & Reinforced Lipids

Deuterated Polyunsaturated Fatty Acids Or Esters Thereof For Cosmetic Applications

US Patent App. 19/091,520·2025·— citations

PatentsD-PUFAs & Reinforced Lipids

Disorders implicating PUFA oxidation

US Patent 12,156,860·2024·1 citations

PatentsD-PUFAs & Reinforced LipidsLipid Peroxidation

Want the full picture?

This article covers just one piece of the puzzle. The book connects all the dots: from the chemistry of aging to the deuterium approach.

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Breaking the Chains of Aging

by Mikhail Shchepinov, PhD

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ISBN 978-1-913460-97-6 · Cloister House Press